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Related Experiment Videos

Atopic dermatitis: is it an allergic disease?

A R Halbert1, W L Weston, J G Morelli

  • 1Department of Dermatology, University of Colorado, Denver 80262, USA.

Journal of the American Academy of Dermatology
|December 1, 1995
PubMed
Summary
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The link between allergy and atopic dermatitis is debated. Current evidence suggests allergy is not central to atopic dermatitis development, questioning routine allergy testing and dietary changes.

Area of Science:

  • Immunology
  • Dermatology
  • Allergology

Background:

  • Atopic dermatitis is a common inflammatory skin condition.
  • The role of allergy in atopic dermatitis pathogenesis has been long debated.

Purpose of the Study:

  • To critically review the evidence linking allergy (IgE-mediated hypersensitivity) to atopic dermatitis.
  • To assess the rationale for allergy testing and environmental/dietary interventions.

Main Methods:

  • Systematic review of existing literature.
  • Critical analysis of studies investigating allergy's contribution to atopic dermatitis.

Main Results:

  • Scant evidence supports allergy as a central factor in atopic dermatitis development.

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  • Allergy may exacerbate symptoms in a subset of patients.
  • Conclusions:

    • Routine allergy testing is not well-justified for most atopic dermatitis patients.
    • Dietary and environmental manipulations lack strong rationale for general management.