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Related Experiment Videos

Atopic dermatitis: is it an allergic disease?

A R Halbert1, W L Weston, J G Morelli

  • 1Department of Dermatology, University of Colorado, Denver 80262, USA.

Journal of the American Academy of Dermatology
|December 1, 1995
PubMed
Summary

The link between allergy and atopic dermatitis is debated. Current evidence suggests allergy is not central to atopic dermatitis development, questioning routine allergy testing and dietary changes.

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Area of Science:

  • Immunology
  • Dermatology
  • Allergology

Background:

  • Atopic dermatitis is a common inflammatory skin condition.
  • The role of allergy in atopic dermatitis pathogenesis has been long debated.

Purpose of the Study:

  • To critically review the evidence linking allergy (IgE-mediated hypersensitivity) to atopic dermatitis.
  • To assess the rationale for allergy testing and environmental/dietary interventions.

Main Methods:

  • Systematic review of existing literature.
  • Critical analysis of studies investigating allergy's contribution to atopic dermatitis.

Main Results:

  • Scant evidence supports allergy as a central factor in atopic dermatitis development.
  • Allergy may exacerbate symptoms in a subset of patients.

Conclusions:

  • Routine allergy testing is not well-justified for most atopic dermatitis patients.
  • Dietary and environmental manipulations lack strong rationale for general management.

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