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Repigmentation in vitiligo vulgaris by autologous minigrafting: results in nineteen patients
B R Boersma1, W Westerhof, J D Bos
1Department of Dermatology, Academic Medical Center, University of Amsterdam, The Netherlands.
Background:
Minigrafting is a successful therapy for localized vitiligo but has never been reported for vitiligo vulgaris.
Objective:
Our purpose was to evaluate the efficacy of minigrafting in vitiligo vulgaris.
Methods:
In 59 patients with stable vitiligo vulgaris, a minigraft test was done by implanting two minigrafts in the lesion to be grafted. Patients were selected for grafting when spread of pigment was observed within 3 months. The rate of repigmentation was evaluated by digital image analysis.
Results:
Twenty-three patients (36 lesions), of 24 with a positive minigraft test, were grafted. The results of 19 patients were analyzed, showing 80% to 99% repigmentation in 14 lesions, 50% to 80% repigmentation in 10 lesions, and zero to 50% repigmentation in 12 lesions. Time of observation varied from 3 to 12 months after grafting. Best results were observed after 9 to 12 months. In all patients with a positive Koebner phenomenon depigmentation of the minigrafts developed.
Conclusion:
Autologous minigrafting is an effective therapy for stable vitiligo vulgaris in a selected group of patients.