Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Adjuncts to antibacterial therapy

M O Frank1, G L Mandell

  • 1Indiana University School of Medicine, Indianapolis, USA.

Infectious Disease Clinics of North America
|September 1, 1995
PubMed
Summary

Modulating the immune system offers new ways to improve antibacterial treatments. Therapies like cytokines and immune globulin can boost the immune response to fight infection effectively.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Post partum creatine phosphokinase and its muscle-brain isoenzyme elevation and transient Q-wave in a patient with idiopathic hypertrophic subaortic stenosis.

International journal of obstetric anesthesia·2004
Same author

Effective antigen cross-presentation by prostate cancer patients' dendritic cells: implications for prostate cancer immunotherapy.

Prostate cancer and prostatic diseases·2004
Same author

Update in infectious diseases.

Annals of internal medicine·2001
Same author

Effect of epidural analgesia with ambulation on labor duration.

Anesthesiology·2001
Same author

Periosteal entrapment of an epidural catheter in the intrathecal space.

Anesthesia and analgesia·2001
Same author

Uptake, transport, and delivery of antimicrobial agents by human polymorphonuclear neutrophils.

Antimicrobial agents and chemotherapy·2001

Area of Science:

  • Immunology
  • Microbiology
  • Pharmacology

Background:

  • Immune system modulation is a promising strategy for enhancing antibacterial therapy.
  • Current approaches include augmenting or attenuating the host's immune response to infection.

Purpose of the Study:

  • To explore strategies for augmenting or attenuating the immune system's response to infection.
  • To highlight the potential of immune modulation in improving antibacterial treatments.

Main Methods:

  • Review of existing and emerging immunomodulatory therapies.
  • Categorization of therapies into those that upregulate (cytokines, growth factors, interferons) or downregulate (corticosteroids) immune responses.
  • Discussion of replacement therapies like immune globulin.

Main Results:

  • Identified cytokines (hematopoietic growth factors, interferons) as agents that upregulate immune response.
  • Recognized immune globulin as a replacement therapy.
  • Highlighted corticosteroids as agents that downregulate immune response.

Conclusions:

  • Immune system augmentation and attenuation represent promising avenues for enhancing antibacterial therapy.
  • Future strategies aim to precisely adjust the host response to maximize microbial inhibition while minimizing inflammatory damage.

Related Experiment Videos