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Collagen injection for intrinsic sphincteric deficiency in men
S R Aboseif1, H E O'Connell, A Usui
1Department of Urology, University of Texas Medical School, Houston 77030, USA.
The Journal of Urology
|January 1, 1996
Summary
Collagen injections effectively treat male urinary incontinence caused by intrinsic sphincter deficiency. This minimally invasive procedure offers a safe and viable option for select patients, improving dryness and reducing pad usage.
Area of Science:
- Urology
- Minimally Invasive Surgery
- Biomaterials
Background:
- Male urinary incontinence is a common complication following prostate surgery and other conditions.
- Intrinsic sphincter deficiency (ISD) is a significant cause of male stress urinary incontinence.
- Current treatment options for ISD have varying success rates and potential complications.
Purpose of the Study:
- To evaluate the efficacy and safety of transurethral collagen injections for treating male urinary incontinence due to intrinsic sphincter deficiency.
- To identify factors associated with treatment success or failure.
Main Methods:
- A prospective study of 88 men with mild to severe ISD treated with collagen injections.
- Patients received an average of 3.5 transurethral collagen injections.
- Outcomes were assessed based on pad usage, with patients categorized by pretreatment incontinence severity.
Main Results:
- Nearly complete dryness was achieved in 42 patients.
- 19 patients showed substantial improvement requiring 1-3 pads daily.
- 13 patients showed no improvement, while 14 used fewer but still more than 3 pads daily.
- The procedure was performed under local anesthesia with no significant morbidity.
Conclusions:
- Collagen injections are an effective, safe, and easily deliverable treatment for select patients with male urinary incontinence due to ISD.
- Factors such as pretreatment incontinence severity, detrusor abnormalities, and etiology of ISD (excluding radical retropubic prostatectomy) negatively impacted treatment outcomes.