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Autocrine motility factor receptor as a possible urine marker for transitional cell carcinoma of the bladder
H J Korman1, J O Peabody, J C Cerny
1Department of Urology, Henry Ford Hospital, Detroit, Michigan 48201, USA.
Purpose:
To determine whether autocrine motility factor receptor (AMFR) is detectable in the urine of patients with transitional cell carcinoma (TCC) of the bladder.
Materials And Methods:
We assayed the urine of 89 patients with bladder pathology and 28 normal controls for AMFR. A monoclonal antibody to AMFR was used.
Results:
All patients with muscle-invasive TCC tested positive for AMFR. Autocrine motility factor receptor was detectable for 80% of superficial tumors, with a correlation between AMFR and tumor grade. Seventy-five percent of control urines tested negative.
Conclusions:
Autocrine motility factor receptor is detectable in the urine of patients with TCC. Long-term follow-up and refinements in the assay should define the marker's utility for detection and prognosis.
