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Detrusor regeneration in the rat using porcine small intestinal submucosal grafts: functional innervation and
J D Vaught1, B P Kropp, B D Sawyer
1Department of Urology, Indiana University School of Medicine, Indianapolis, USA.
Purpose:
To evaluate functional characteristics of regenerated bladder induced by small intestinal submucosa (SIS).
Materials And Methods:
Strips from bladder regenerated from SIS and normal rat bladder were evaluated by in vitro muscle bath contractility studies.
Results:
The present results indicate that SIS-regenerated bladder 1) demonstrates contractile activity; 2) expresses muscarinic, purinergic and beta adrenergic receptors; and 3) exhibits functional cholinergic and purinergic innervation that is similar to the normal rat urinary bladder muscle.
Conclusions:
These functional characteristics of SIS-regenerated tissue demonstrated in the present study further support use of SIS material as a bladder augmentation material.