Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Glutaric aciduria: improved MR appearance after aggressive therapy

C H Cho1, A C Mamourian, J Filiano

  • 1Department of Diagnostic Radiology, Dartmouth Hitchock Medical Center, Lebanon, NH 03756, USA.

Pediatric Radiology
|January 1, 1995
PubMed
Summary

Glutaric aciduria, a metabolic disorder, causes brain abnormalities. Dietary therapy and illness management significantly improved these findings on CT and MR scans in a patient.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A randomized phase III clinical trial of weekly versus tri-weekly cisplatin-based chemoradiotherapy for locally advanced cervical cancer: results of the TACO (GCIG/KGOG 1027/THAI 2012) study.

ESMO open·2026
Same author

Involvement of autophagy in antibacterial actions of vitamin D in <i>Helicobacter pylori</i> infection: abridged secondary publication.

Hong Kong medical journal = Xianggang yi xue za zhi·2020
Same author

Do All Patients with Multiple Sclerosis Benefit from the Use of Contrast on Serial Follow-Up MR Imaging? A Retrospective Analysis.

AJNR. American journal of neuroradiology·2018
Same author

Editorial.

Current medicinal chemistry·2017
Same author

Adenosine A<sub>2A</sub> receptor and ERK-driven impulsivity potentiates hippocampal neuroblast proliferation.

Translational psychiatry·2017
Same author

Identification of pathogenic microRNAs in Helicobacter pylori-associated gastric cancer using a combined approach of animal study and clinical sample analysis.

Hong Kong medical journal = Xianggang yi xue za zhi·2016

Area of Science:

  • Biochemistry
  • Neurology
  • Medical Imaging

Background:

  • Glutaric aciduria is an inborn error of metabolism.
  • Understanding metabolic abnormalities aids diagnosis and therapy.
  • Brain abnormalities are associated with glutaric aciduria.

Observation:

  • CT and MR imaging reveal fronto-temporal atrophy, large insular cisterns, and white matter hypodensities.
  • A patient with glutaric aciduria presented with these characteristic brain abnormalities.
  • Enzymatic assays confirmed the diagnosis of glutaric aciduria.

Findings:

  • The patient's brain imaging showed typical findings of glutaric aciduria.
  • Repeat imaging after treatment demonstrated significant improvement.
  • Therapeutic interventions included dietary changes and catabolism prevention.

Related Experiment Videos

Implications:

  • Early biochemical diagnosis and prompt treatment are crucial for managing glutaric aciduria.
  • Neuroimaging can monitor treatment response in patients with glutaric aciduria.
  • Effective management can lead to reversible brain changes in metabolic disorders.