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Related Experiment Videos

Defibrillation thresholds are lower with smaller storage capacitors

F M Leonelli1, M W Kroll, J E Brewer

  • 1University of Kentucky Medical Center, Cardiology Division, Lexington 40536, USA.

Pacing and Clinical Electrophysiology : PACE
|September 1, 1995
PubMed
Summary
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A smaller capacitance in implantable cardioverter defibrillators may lower the defibrillation threshold (DFT). This study found that an 85-microfarad capacitor required less energy for defibrillation compared to a 140-microfarad capacitor in dogs.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Medical Devices

Background:

  • Implantable cardioverter defibrillators (ICDs) utilize varying capacitance values for energy storage.
  • The optimal capacitance for ICDs remains undetermined.
  • Smaller capacitors may align better with cardiac chronaxie, potentially reducing the defibrillation threshold (DFT).

Purpose of the Study:

  • To investigate the effect of different capacitance values on the DFT in a canine model.
  • To determine if a smaller capacitor (85 microfarads) is more effective than a larger one (140 microfarads) in achieving defibrillation.

Main Methods:

  • Comparison of defibrillation energy using 85-microfarad and 140-microfarad capacitors in 10 open-chest dogs.
  • Ventricular fibrillation was induced for 15 seconds.

Related Experiment Videos

  • Monophasic, time-truncated waveforms were delivered via epicardial patch electrodes.
  • A modified 3-reversal method was used for DFT determination.

    • Main Results:

    • The 85-microfarad capacitor demonstrated significantly lower average stored (6.0 J vs. 6.7 J) and delivered (5.2 J vs. 6.0 J) DFT energies (P = 0.01 and P = 0.004, respectively).
    • The 85-microfarad capacitor resulted in higher leading edge voltages, shorter pulse durations, and lower mean impedance.
    • Waveform characteristics, including impedance and pulse duration, appeared to influence defibrillation efficacy.

    Conclusions:

    • A smaller capacitance (85 microfarads) is associated with a lower DFT compared to a larger capacitance (140 microfarads).
    • Electrical waveform characteristics, influenced by capacitance, play a role in defibrillation effectiveness.
    • No significant differences in post-shock arrhythmias or hypotension were observed between the two capacitor sizes.