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[Pseudolithiasis caused by ceftriaxone in children: a case report]
M Benedetti1, S Zanchetta, A Bagnani
1Divisione di Pediatria, Ospedale S. Giovanni Battista di Soave, U.L.S.S. 20, Verona, Italia.
Insights
Ceftriaxone treatment can cause temporary gallbladder precipitates, known as pseudolithiasis, in children. These precipitates usually resolve after stopping the antibiotic, with normal gallbladder function returning over time.
Area of Science:
- Pediatric Gastroenterology
- Pharmacology
- Diagnostic Imaging
Background:
- Reports indicate transient gallbladder precipitates during ceftriaxone therapy in pediatric and adult patients.
- This phenomenon, termed ceftriaxone-reversible pseudolithiasis, is characterized by precipitates that resolve spontaneously post-treatment.
Observation:
- A case study of a 1-year-old child treated with ceftriaxone is presented.
- The child developed asymptomatic pseudolithiasis, which showed partial resolution two weeks after discontinuing ceftriaxone.
- Follow-up sonography four months after cessation revealed a normal gallbladder without precipitates or sludge.
Findings:
- The case demonstrates that ceftriaxone-induced gallbladder pseudolithiasis in a pediatric patient can be asymptomatic.
- Partial resolution of precipitates was observed shortly after treatment cessation.
- Complete resolution of gallbladder precipitates was confirmed several months after ceftriaxone discontinuation.
Implications:
- This case reinforces the understanding of ceftriaxone-associated gallbladder pseudolithiasis in children.
- The findings suggest that sonographic monitoring may be warranted in pediatric patients receiving ceftriaxone.
- Complete resolution indicates a reversible effect, reassuring for long-term gallbladder health.
Abstract:
Recently, there are in literature some reports concerning the sonographic observation of transient gallbladder precipitates in children and adults during ceftriaxone treatment. The condition is defined as ceftriaxone-reversible "pseudolithiasis" and the gallbladder precipitates resolve spontaneously after cessation of therapy. We present a case of a 1 year old children treated with ceftriaxone who presented asymptomatic pseudolithiasis that resolved partially two weeks after cessation of treatment. The sonographic observation performed four months after cessation of therapy show a normally gallbladder, without precipitates or sludge.