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Melasma. Etiologic and therapeutic considerations

P E Grimes1

  • 1Division of Dermatology, King-Drew Medical Center, Los Angeles, Calif.

Archives of Dermatology
|December 1, 1995
PubMed
Summary

Melasma, a common skin hyperpigmentation, presents therapeutic challenges. Treatment options like bleaching agents, peels, and lasers must balance efficacy with potential risks and psychosocial impact.

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Area of Science:

  • Dermatology
  • Cosmetic Science

Background:

  • Melasma is a common acquired hyperpigmentation affecting sun-exposed skin.
  • Key factors include genetics, UV radiation, hormones, and certain medications.

Purpose of the Study:

  • To review current therapeutic approaches for melasma.
  • To highlight the challenges in treating this condition.

Main Methods:

  • Review of existing literature on melasma treatments.
  • Analysis of hypopigmenting agents, chemical peels, and laser therapies.

Main Results:

  • Hydroquinone remains a primary topical agent despite ochronosis concerns.
  • Tretinoin and azelaic acid are alternative nonphenolic agents.
  • Chemical peels and lasers show variable efficacy and require cautious application.

Conclusions:

  • Treatment selection requires careful consideration of benefits, risks, and psychosocial effects.
  • Physicians must weigh the impact of pigmentary imperfections against treatment outcomes.

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