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Related Experiment Videos

A non-electrostatic spacer for aerosol delivery

H Bisgaard1, J Anhøj, B Klug

  • 1Department of Paediatrics, National University Hospital, Copenhagen, Denmark.

Archives of Disease in Childhood
|September 1, 1995
PubMed
Summary

A novel steel spacer device significantly improves budesonide delivery from metered dose inhalers in children with asthma. This non-electrostatic spacer offers more reliable and cost-effective aerosol treatment compared to plastic alternatives.

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Area of Science:

  • Respiratory Medicine
  • Pharmaceutical Technology
  • Pediatric Pulmonology

Background:

  • Pressurized metered dose inhalers (p-MDI) are crucial for delivering inhaled medications.
  • Spacer devices enhance p-MDI efficacy by reducing coordination needs and impaction.
  • Electrostatic charges on plastic spacers can affect aerosol deposition and drug delivery.

Purpose of the Study:

  • To compare the dose delivery efficiency of a novel non-electrostatic steel spacer with existing plastic spacers.
  • To evaluate the impact of spacer material and design on budesonide aerosol delivery in vitro and in children with asthma.

Main Methods:

  • A pear-shaped, 250 ml steel spacer with integrated valves was tested against three plastic spacers (Nebuhaler, Babyhaler, AeroChamber).
  • In vitro studies assessed aerosol half-life and maximum delivered dose of budesonide from a p-MDI.

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  • A clinical study in 124 children (6 months to 6 years) with suspected asthma measured delivered budesonide dose.

    • Main Results:

    • The steel spacer exhibited a stable aerosol half-life (27 seconds) independent of p-MDI priming or cleaning.
    • In vitro, the steel spacer delivered 56% of the nominal budesonide dose, higher than AeroChamber (30%) but lower than Nebuhaler (61%).
    • In children, the steel spacer delivered a significantly higher mean budesonide dose (39%) compared to Babyhaler (28%), Nebuhaler (21%), and AeroChamber (19%), especially in those under 4 years.

    Conclusions:

    • The non-electrostatic steel spacer provides superior and more consistent budesonide delivery compared to plastic spacers in young children.
    • The device's material and unidirectional valves contribute to improved aerosol deposition and potentially enhanced treatment cost-effectiveness.
    • This spacer design mitigates issues related to electrostatic charge, priming, and cleaning, ensuring more reliable inhaled therapy.