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Published on: April 25, 2016
Filter paper cortisol profiles in secondary adrenocortical insufficiency
J S Sieratzki1, C Gompels, K Poyser
1Bristol Royal Hospital for Sick Children.
Archives of Disease in Childhood
|October 1, 1995
Summary
Filter paper cortisol profiles effectively diagnose and manage secondary adrenocortical deficiency in children. This simple, non-invasive method aids in monitoring treatment for hypocortisolism.
Area of Science:
- Pediatric Endocrinology
- Endocrinology
- Clinical Chemistry
Background:
- Secondary adrenocortical deficiency is a critical condition in children with pituitary disorders.
- Accurate diagnosis and management are essential for patient outcomes.
- Traditional cortisol testing methods can be invasive or insufficient.
Purpose of the Study:
- To evaluate the utility of 24-hour filter paper cortisol profiles for diagnosing and managing secondary adrenocortical deficiency in children.
- To compare filter paper cortisol measurements with conventional assessments.
Main Methods:
- Analysis of 24-hour filter paper cortisol profiles in children with familial short stature and growth hormone deficiency.
- Assessment of children with multiple pituitary hormone deficiencies and those on replacement therapy.
- Comparison of filter paper results with baseline plasma cortisol and responses to stimulation tests.
Main Results:
- Children with isolated growth hormone deficiency showed normal cortisol levels.
- A significant proportion of children with multiple pituitary hormone deficiencies exhibited hypocortisolism, even with normal baseline tests.
- Most children on replacement treatment had adequate cortisol levels, though morning samples were often low.
Conclusions:
- 24-hour filter paper cortisol profiles offer a simple, cost-effective, and minimally invasive approach for managing pediatric hypocortisolism.
- This method is valuable for both diagnosis and treatment monitoring in children with suspected adrenocortical insufficiency.
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