Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Glutamate receptor dysfunction and schizophrenia

J W Olney¹, N B Farber

¹Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.

Archives of General Psychiatry

|December 1, 1995

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Isoflurane exposure for three hours triggers apoptotic cell death in neonatal macaque brain.

British journal of anaesthesia·2017

Same author

The use of electroconvulsive therapy in a patient with juvenile systemic lupus erythematosus and catatonia.

Lupus·2012

Same author

NMDA receptor function, memory, and brain aging.

Dialogues in clinical neuroscience·2011

Same author

Acute neonatal glucocorticoid exposure produces selective and rapid cerebellar neural progenitor cell apoptotic death.

Cell death and differentiation·2008

Same author

Prolonged exposure to inhalational anesthetic nitrous oxide kills neurons in adult rat brain.

Neuroscience·2003

Same author

Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain.

Cell death and differentiation·2003

Same journal

Reviewers Who Completed a Review During 2011.

Archives of general psychiatry·2017

Same journal

Conflicts of interest-reply.

Archives of general psychiatry·2013

Same journal

Epidemiologic evidence concerning the bereavement exclusion in major depression-reply.

Archives of general psychiatry·2013

Same journal

This month in archives of general psychiatry.

Archives of general psychiatry·2013

Same journal

About this journal.

Archives of general psychiatry·2013

Same journal

This month in archives of general psychiatry.

Archives of general psychiatry·2013

See all related articles

This study proposes that reduced function of N-methyl-D-aspartate (NMDA) receptors, combined with dopamine dysfunction, explains schizophrenia

Area of Science:

Neuroscience
Psychiatry
Pharmacology

Background:

Schizophrenia presents complex clinical and pathophysiological features.
Existing hypotheses do not fully explain all aspects of the disorder.

Purpose of the Study:

To propose a unified hypothesis for schizophrenia.
To highlight N-methyl-D-aspartate (NMDA) receptor hypofunction as a central mechanism.

Main Methods:

Review and synthesis of existing research on dopamine and NMDA receptor function.
Integration of developmental, clinical, and neurobiological findings.

Main Results:

The hypothesis accommodates early brain changes, a quiescent period, adult-onset psychosis, variable dopamine D2 receptor involvement, and neurodegeneration.

Related Experiment Videos

NMDA receptor hypofunction can induce psychosis and neurodegeneration, which are preventable by certain antipsychotics.

Conclusions:

NMDA receptor hypofunction is a key mechanism in schizophrenia.
Understanding NMDA receptor dysfunction may improve antipsychotic pharmacotherapy.