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Antifungal steroidal lactones from Withania coagulance
M I Choudhary1, Dur-e-Shahwar, Z Parveen
1H.E.J. Research Institute of Chemistry, University of Karachi, Pakistan.
Phytochemistry
|November 1, 1995
Abstract:
Two new withanolides, 14,15 beta-epoxywithanolide I [(20S,22R) 17 beta, 20 beta-dihydroxy-14 beta,15 beta-epoxy-1-oxo-witha-3,5,24-trienolide] and 17 beta-hydroxywithanolide K (20S,22R) 14 alpha,17 beta,20 beta-trihydroxy-1-oxo-witha-2,5,24-trienolide] have been isolated from the whole plant of Withania coagulance and their structures were elucidated by spectroscopic techniques. The latter compound was found to be active against a number of potentially pathogenic fungi.