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Methodology for selecting substances for the National Exposure Registry

G L Gist1, J R Burg

  • 1Agency for Toxic Substances and Disease Registry, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia 30333, USA.

Journal of Exposure Analysis and Environmental Epidemiology
|April 1, 1995
PubMed
Summary

The National Exposure Registry tracks human health outcomes from long-term, low-level exposure to chemical contaminants at waste sites. A ranking system identifies priority substances for specialized subregistries, including volatile organic compounds and heavy metals.

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Area of Science:

  • Environmental Health
  • Toxicology
  • Public Health Surveillance

Background:

  • Pervasive chemical contamination at national waste sites necessitates better understanding of human health impacts.
  • Limited data exists on health outcomes from long-term, low-level exposure to common environmental contaminants.
  • The Agency for Toxic Substances and Disease Registry (ATSDR) identified a need for systematic exposure tracking.

Purpose of the Study:

  • To establish the National Exposure Registry to address data gaps in human health outcomes related to environmental chemical exposures.
  • To develop a systematic method for selecting priority chemical substances for detailed study within the registry.
  • To create substance-specific subregistries for critical environmental contaminants.

Main Methods:

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  • Development of a substance ranking scheme by ATSDR using decision analysis.
  • Incorporation of current data on substances found at known ATSDR waste sites.
  • Establishment of four general subregistries: volatile organic compounds, dioxins, heavy metals, and radioactive substances.

    • Main Results:

    • A robust ranking scheme was successfully developed and implemented by ATSDR.
    • The National Exposure Registry now includes four specialized subregistries based on contaminant type.
    • The registry focuses on individuals exposed to specific primary contaminants identified through the ranking process.

    Conclusions:

    • The National Exposure Registry provides a framework for investigating health effects of environmental exposures.
    • The developed ranking scheme effectively prioritizes chemical substances for public health surveillance.
    • The registry's subregistries facilitate targeted research on specific contaminant exposures and associated health outcomes.