Related Experiment Video
Updated: Aug 19, 2026

Creating and Applying a Reference to Facilitate the Discussion and Classification of Proteins in a Diverse Group
Published on: August 16, 2017
beta-Glucosidase families revealed by computer analysis of protein sequences
1University of Rovira i Virgili, Department of Biochemistry and Biotechnology, Tarragona, Spain.
Abstract:
This computational study is a summary of how cloned beta-glucosidase subfamilies are organized. Computations were carried out using General Computer Group, Inc. (GCG) package programs. Twenty-two beta-glucosidases belonging to either cellulolytic or non-cellulolytic organisms were identified. The multialignment of a whole beta-glucosidase family is shown. Two sub-families, A and B, were clearly seen to exist. Sub-family A is further subdivided into sub-families A1 and A2. A1 includes vegetal beta-glucosidases and A2 includes prokaryotic enzymes. Sub-family B has three new sub-families, B1, B2, and B3. The enzymes in B2 are of yeast and/or fungi. Aspartic (D), glutamic (E) and histidine (H) residues, which are thought to be a part of the mechanism of the enzymatic hydrolysis are conserved. The well conserved amino acid sequences of the sub-family A are ITENGA; QUIEGA; HVD; and NEP. The well conserved amino acid sequences of the sub-family B are: SDW; and YN(R,K)(V,L)N.
Related Concept Videos
Gene Families
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
Protein Families
Protein Complexes with Interchangeable Parts
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Oligosaccharide Assembly
Multiple sugar molecules that may or may...
Evolutionary Relationships through Genome Comparisons
Protein Folding Quality Check in the RER

