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Antiallergic constituents from oolong tea stem

Y Ohmori1, M Ito, M Kishi

  • 1Biochemical Research Institute, Nippon Menard Cosmetic Co., Ltd., Gifu, Japan.

Biological & Pharmaceutical Bulletin
|May 1, 1995
PubMed
Summary

Oolong tea stem extracts show antiallergic properties, inhibiting allergic reactions. (-)-gallocatechin gallate (GCG) emerged as a potent novel tea catechin with significant anti-allergic activity.

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Area of Science:

  • Pharmacology
  • Natural Products Chemistry
  • Immunology

Background:

  • Oolong tea is known for its potential health benefits.
  • Previous research suggests tea constituents possess antiallergic properties.

Purpose of the Study:

  • To identify and characterize the antiallergic compounds present in oolong tea stems.
  • To evaluate the efficacy of isolated tea catechins in inhibiting allergic responses.

Main Methods:

  • Extraction and fractionation of oolong tea stem components using various solvents.
  • Inhibition assays for passive cutaneous anaphylaxis (PCA) reactions in rats.
  • Assessment of histamine release from rat peritoneal mast cells.
  • Isolation and identification of six major tea catechins.

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Main Results:

  • Oolong tea stem extracts demonstrated significant dose-dependent inhibition of PCA reactions, comparable to ketotifen.
  • Ethyl acetate and chloroform fractions contained the primary antiallergic activity.
  • Among isolated catechins, (-)-gallocatechin gallate (GCG) exhibited the most potent inhibition of histamine release, surpassing (-)-epigallocatechin gallate (EGCG).

Conclusions:

  • Oolong tea stems contain potent antiallergic constituents, primarily tea catechins.
  • (-)-gallocatechin gallate (GCG) is identified as a novel and highly effective antiallergic compound within tea catechins.