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Trophic factor supplementation: effect on the age-associated changes in body composition

R S Schwartz1

  • 1University of Washington School of Medicine, Division of Gerontology and Geriatric Medicine, Harborview Medical Center, Seattle, USA.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|November 1, 1995
PubMed
Summary

Aging alters body composition and trophic factors like growth hormone and sex hormones. Supplementation shows potential clinical effects in older individuals, warranting further research into these hormonal changes.

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Area of Science:

  • Endocrinology
  • Gerontology
  • Metabolic Research

Background:

  • Aging is associated with body composition changes mirroring growth hormone deficiency.
  • Elderly individuals exhibit abnormalities in growth hormone/insulin-like growth factors and sex hormone systems.

Purpose of the Study:

  • To review age-related changes in growth hormone and sex steroid axes.
  • To examine the clinical effects of trophic factor supplementation in the elderly.

Main Methods:

  • Literature review of studies on aging, hormonal axes, and trophic factor supplementation.
  • Analysis of age-related alterations in endocrine systems.

Main Results:

  • Aging impacts the growth hormone and sex steroid axes significantly.

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  • Trophic factor supplementation is of intense clinical interest for older individuals.

    • Conclusions:

    • Understanding age-related hormonal changes is crucial for geriatric health.
    • Future research should address key questions regarding trophic factor use in the elderly.