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[Electron-microscopic study of the relationship between influenza A virus (H3N2) and human peripheral blood
Voprosy Virusologii
|July 1, 1978
Abstract:
The electron microscopic examinations of formed elements of human peripheral blood infected with a freshly isolated A/Sev/76 virus strain and vaccine A/Victoria/36/72 virus demonstrated that virions of both strains adsorbed on neutrophils, lymphocytes, monocytes, thrombocytes and penetrated into the cells by phagocytosis and viropexis; most virus was concentrated in neutrophils and thrombocytes.
Insights
Both wild-type and vaccine influenza A virus strains infect human blood cells, including neutrophils and platelets. Electron microscopy revealed virus entry via phagocytosis and viropexis, with highest concentrations in neutrophils and thrombocytes.
Area of Science:
- Virology
- Hematology
- Cell Biology
Context:
- Investigating the interaction between influenza A virus strains and human peripheral blood cells.
- Utilizing electron microscopy to visualize viral entry mechanisms at the cellular level.
Purpose:
- To determine which blood cell types are susceptible to influenza A virus infection.
- To elucidate the methods by which influenza A virus enters human blood cells.
Summary:
- Electron microscopic examination of human peripheral blood cells infected with A/Sev/76 (H1N1) and A/Victoria/36/72 influenza virus strains.
- Demonstrated adsorption and penetration of virions into neutrophils, lymphocytes, monocytes, and thrombocytes via phagocytosis and viropexis.
- Observed the highest concentration of influenza virus within neutrophils and thrombocytes.
Impact:
- Provides insights into the cellular tropism of influenza A viruses within the human bloodstream.
- Highlights the role of neutrophils and thrombocytes as key sites for viral replication or accumulation.
- Informs understanding of viral pathogenesis and host-cell interactions during influenza infection.