Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diminished mononuclear cell function is associated with chronic venous insufficiency

P J Pappas1, E P Teehan, S R Fallek

  • 1Department of Surgery, UMDNJ-New Jersey Medical School, Newark 07103-2714, USA.

Journal of Vascular Surgery
|November 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rapid and possibly nongenomic effects of testosterone on isolated and perfused rat heart.

Proceedings of the Western Pharmacology Society·1998
Same author

[Yield of xenodiagnosis and PCR in the evaluation of specific chemotherapy of Chagas' disease in children].

Boletin chileno de parasitologia·1998
Same author

[Percutaneous suprapubic bladder lithotripsy].

Annales d'urologie·1998
Same author

Factors associated with outcome in major depression: a 6-month prospective study.

Social psychiatry and psychiatric epidemiology·1998
Same author

[Simultaneous transplantation of fetal mesencephalic cells to the striatum and globus pallidus of rats with lesions induced by 6-hydroxydopamine].

Revista de neurologia·1998
Same author

Signs of glaucoma in rhesus monkeys from a restricted gene pool.

Journal of glaucoma·1998
Same journal

Frailty is associated with fewer hospital-free days following peripheral artery disease revascularization.

Journal of vascular surgery·2026
Same journal

Shifting Burden of Major Lower Extremity Amputations Across Hospital Medicaid Burden and Socioeconomic Groups, 1993-2021.

Journal of vascular surgery·2026
Same journal

The United Kingdom Branch Endoprosthesis for Aortic arch Treatment study (UK-BEAT): Early experience with the GORE TAG thoracic branch endoprosthesis.

Journal of vascular surgery·2026
Same journal

Association of revascularization strategy with wound healing following toe amputation in chronic limb-threatening ischemia.

Journal of vascular surgery·2026
Same journal

Premature peripheral arterial disease (PAD) is associated with worse outcomes after endovascular peripheral vascular intervention.

Journal of vascular surgery·2026
Same journal

Self-Expandable versus Balloon-Expandable Bridging Stents in Off-the-Shelf Inner Branch Repair: Midterm Results from the INBREED Registry.

Journal of vascular surgery·2026
See all related articles

Mononuclear cell function deteriorates with chronic venous insufficiency (CVI), impacting wound healing. Patients with CVI show reduced cell proliferation, particularly those with active ulcers or lipodermatosclerosis, indicating a link to disease progression.

Area of Science:

  • Immunology
  • Vascular Biology
  • Dermatology

Background:

  • Chronic venous insufficiency (CVI) is linked to increased dermal mononuclear cells.
  • Dysfunctional immune cells may explain impaired wound healing in CVI patients.

Purpose of the Study:

  • To investigate potential dysfunction in monocytes from patients with CVI.
  • To correlate monocyte function with the clinical severity of CVI.

Main Methods:

  • Mononuclear cell proliferation was assessed in response to mitogens (staphylococcal enterotoxins and PHA).
  • Fifty patients were categorized into four groups based on CVI severity and ulcer status.
  • Cellular responses were analyzed using statistical comparisons between groups.

Main Results:

Related Experiment Videos

  • Lymphocytes and monocytes in CVI patients were not globally impaired but showed reduced PHA response in Class 2 CVI.
  • Significant reductions in proliferative responses to staphylococcal enterotoxins A and B were observed in CVI groups.
  • A trend of diminished mononuclear cell function correlated with CVI progression, with lipodermatosclerosis patients showing the poorest responses.

Conclusions:

  • Mononuclear cell dysfunction is associated with CVI.
  • Diminishing proliferative capacity with disease progression suggests clinical significance.
  • Impaired mononuclear cell proliferation may contribute to poor wound healing in CVI.