Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chronic hibernating myocardium: interstitial changes

J Ausma1, J Cleutjens, F Thoné

  • 1Department of Molecular Cell Biology and Genetics, Cardiovascular Research Institute Maastricht, University of Limburg, The Netherlands.

Molecular and Cellular Biochemistry
|June 7, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Response to exercise and mechanical efficiency in non-ischaemic stunning, induced by short-term rapid pacing in dogs: a role for calcium?

Acta physiologica (Oxford, England)·2015
Same author

Ultrastructural calcium distribution and myocardial calcium content in human idiopathic dilated cardiomyopathy.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
Same author

Chronic ischemic viable myocardium in man: Aspects of dedifferentiation.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
Same author

Contact sites between the inner and outer mitochondrial membranes in stunned versus hibernating myocardium.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2015
Same author

Chronic hibernating myocardium in sheep can occur without degenerating events and is reversed after revascularization.

Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology·2014
Same author

Cytoskeleton-modulation in growth and development.

Cytotechnology·2012
Same journal

PER1 reduces HIF-1α nuclear accumulation and modulates vascular remodeling in hepatocellular carcinoma.

Molecular and cellular biochemistry·2026
Same journal

FCGR2A promoter variant reveals shared genetic susceptibility between IBD and stroke.

Molecular and cellular biochemistry·2026
Same journal

Chlamydia psittaci induces GSDME-mediated pyroptosis via the ROS-JNK signaling pathway.

Molecular and cellular biochemistry·2026
Same journal

Pentraxin 3 is an inflammation-related biomarker that distinguishes early-stage from mid-advanced cardiovascular-kidney-metabolic syndrome.

Molecular and cellular biochemistry·2026
Same journal

High glucose-induced mitochondrial fission promotes Müller cell activation via suppression of the Hippo pathway.

Molecular and cellular biochemistry·2026
Same journal

Correction to: Estradiol inhibits vascular endothelial cells pro-inflammatory activation induced by C-reactive protein.

Molecular and cellular biochemistry·2026
See all related articles

Chronic myocardial hibernation involves cardiomyocyte de-differentiation and increased interstitial tissue, including collagen and fibronectin. This structural remodeling hinders immediate functional recovery after blood flow restoration in left ventricular dysfunction.

Area of Science:

  • Cardiovascular Biology
  • Cardiac Pathophysiology
  • Myocardial Remodeling

Background:

  • Chronic hibernation in left ventricular dysfunction involves viable but dysfunctional myocardium.
  • Structural changes include contractile element depletion and cardiomyocyte de-differentiation.
  • These changes are associated with significant alterations in the interstitial space.

Purpose of the Study:

  • To describe qualitative and quantitative changes in the cellular and non-cellular interstitial compartments.
  • To investigate the role of interstitial remodeling in impaired cardiac function recovery.

Main Methods:

  • Histological analysis of myocardial segments from patients with chronic left ventricular dysfunction.
  • Qualitative and quantitative assessment of interstitial space components.

Related Experiment Videos

  • Immunohistochemical detection of vimentin-positive cells.

    • Main Results:

    • Cardiomyocytes show de-differentiation, not degeneration.
    • Increased interstitial space is filled with type I collagen, type III collagen, and fibronectin.
    • An increased number of vimentin-positive cells (endothelial cells, fibroblasts) is observed.

    Conclusions:

    • Interstitial fibrosis and cellular changes are key features of chronic myocardial hibernation.
    • Increased interstitial tissue contributes significantly to the delayed recovery of contractile function post-reperfusion.
    • Understanding these structural changes is crucial for managing left ventricular dysfunction.