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Breast cancer in the elderly

M Bellet1, C Alonso, B Ojeda

  • 1Department of Medical Oncology, Hospital Sta Creu i Sant Pau, Barcelona, Spain.

Postgraduate Medical Journal
|November 1, 1995
PubMed
Summary

This review examines breast cancer in elderly patients, highlighting scarce data and conflicting treatment outcomes. It analyzes standard and less aggressive therapies, including tamoxifen and systemic treatments for advanced stages.

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Area of Science:

  • Geriatric Oncology
  • Clinical Breast Cancer Research

Background:

  • Increasing incidence of breast cancer in the geriatric population.
  • Limited data on clinical and biological profiles of breast cancer in elderly patients.
  • Conflicting evidence on the effectiveness of various breast cancer treatments for older adults.

Purpose of the Study:

  • To characterize breast cancer in the elderly, including histology, stage at diagnosis, and outcomes.
  • To review the feasibility and efficacy of standard therapies (surgery, radiotherapy) versus less aggressive approaches.
  • To critically evaluate tamoxifen as primary or adjuvant therapy and discuss systemic treatments for advanced disease.

Main Methods:

  • Literature review focusing on breast cancer in elderly patients.
  • Analysis of histological patterns, diagnostic stage, and patient outcomes.
  • Comparative assessment of standard surgical and radiotherapeutic interventions against conservative methods.

Main Results:

  • Detailed analysis of standard breast cancer therapies' applicability in the elderly.
  • Comparison of efficacy between aggressive and conservative treatment modalities.
  • Critical review of tamoxifen's role as primary and adjuvant treatment, and systemic therapy for advanced cases.

Conclusions:

  • The review provides a comprehensive overview of breast cancer characteristics and treatment options in the elderly.
  • It highlights the need for tailored therapeutic strategies considering patient age and comorbidities.
  • Further research is warranted to optimize breast cancer management in the geriatric population.

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