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Compressed donut-shaped tablets with zero-order release kinetics

C J Kim1

  • 1School of Pharmacy, Temple University, Philadelphia, Pennsylvania 19140, USA.

Pharmaceutical Research
|July 1, 1995
PubMed
Summary
This summary is machine-generated.

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Donut-shaped tablets with a central hole offer controlled drug release, achieving zero-order kinetics by minimizing surface area effects. Hole size impacts release rate and duration, with larger holes shortening release time.

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Controlled drug delivery systems aim for constant therapeutic levels.
  • Tablet geometry significantly influences drug release profiles.

Purpose of the Study:

  • To investigate the drug release kinetics of donut-shaped tablets.
  • To evaluate the impact of central hole size and drug solubility on release.

Main Methods:

  • Polyethylene oxide (PEO) tablets (600 mg, 12 mm diameter) were fabricated.
  • Tablets featured central holes of varying sizes (3/32" to 5/32").
  • Theophylline release was monitored over time.

Main Results:

  • Donut-shaped tablets exhibited zero-order theophylline release (80-90%).

Related Experiment Videos

  • Increased hole size accelerated release rate and shortened duration.
  • Smaller holes (3/32") showed anomalous release similar to non-holed tablets.
  • Higher drug solubility reduced linear release duration and increased tailing.

    • Conclusions:

    • Donut-shaped tablets facilitate zero-order drug release.
    • Reduced surface area effect in donut-shaped tablets is key to sustained release.
    • Tablet design, including hole size, is critical for predictable drug delivery.