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[The evaluation of cilazapril efficacy in patients with stable arterial hypertension (a randomized study)]

Iu B Belousov, Sh V Akhadov, M V Leonova

    Terapevticheskii Arkhiv
    |January 1, 1995
    PubMed

    Insights

    Cilazapril showed limited antihypertensive effects in patients with stable arterial hypertension, particularly those with higher mean arterial pressure. Hemodynamic improvements were observed only in patients with elevated end-diastolic left ventricular volume.

    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Stable arterial hypertension (AH) affects a significant portion of the adult population.
    • Effective antihypertensive medications are crucial for managing AH and preventing complications.

    Purpose of the Study:

    • To evaluate the efficacy of cilazapril in patients with stable arterial hypertension.
    • To assess the dose-dependent effects of cilazapril on hemodynamics.

    Main Methods:

    • A randomized study involving 34 patients with stable arterial hypertension.
    • Patients were randomized based on mean arterial pressure (MAP), end-diastolic LV volume, and cardiac output.
    • Cilazapril was administered at doses of 2.5 mg/day and 5 mg/day.

    Main Results:

    • The antihypertensive effect was insufficient in most patients with MAP ranging from 120-135 mm Hg and 136-150 mm Hg, with diastolic pressure remaining above 94 mm Hg.
    • No dose-effect relationship was observed regarding hemodynamics.
    • Hemodynamic benefits were primarily noted in patients with end-diastolic LV volume greater than 5.0-5.7 cm.

    Conclusions:

    • Cilazapril demonstrated limited efficacy in lowering blood pressure in the majority of patients with stable arterial hypertension, irrespective of the dose.
    • The drug's hemodynamic benefits were restricted to a subgroup of patients with specific baseline end-diastolic left ventricular volumes.

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