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Hypercoagulable state indicates an additional risk factor for atherosclerosis in Werner's syndrome
Thrombosis and Haemostasis
|April 1, 1995
Summary
Werner's syndrome (WS) patients exhibit increased risk factors for atherosclerosis, including hypercoagulable states and elevated lipids. These findings suggest additional pathways contributing to cardiovascular disease in WS beyond known factors.
Area of Science:
- Cardiovascular Medicine
- Genetics
- Hematology
Background:
- Werner's syndrome (WS) is a rare genetic disorder characterized by premature aging.
- Atherosclerosis is a significant concern in WS patients, but its risk factors require further elucidation.
Purpose of the Study:
- To investigate coagulation/fibrinolytic system parameters and lipid profiles in WS patients.
- To identify novel risk factors for atherosclerosis in Werner's syndrome.
Main Methods:
- Analysis of coagulation and fibrinolytic markers in 9 non-smoker WS patients.
- Comparison of WS patient data with normal control values.
- Lipid profile assessment, including screening for hyperlipidemia, hyperinsulinemia, and diabetes mellitus.
Main Results:
- Significantly elevated levels of thrombin antithrombin III complex, D-dimer, tissue plasminogen activator, and plasminogen activator inhibitor 1 were observed in WS patients.
- A significant decrease in fasting plasma thrombomodulin levels was noted in WS cases.
- Lipid profiles revealed hyperlipidemia type IIb in 8/9 patients, hyperinsulinemia in 7, and clinical diabetes mellitus in 5.
Conclusions:
- WS patients present a hypercoagulable condition, indicating multiple atherosclerosis risk factors.
- These findings add to the known risks of hyperinsulinemia and hyperlipidemia in WS.
- The study highlights the complex interplay of genetic factors and metabolic disturbances in accelerating atherosclerosis in Werner's syndrome.