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Decrease in platelet survival and total platelet sialic acid concentration in rats infected with Plasmodium bergei

A L Inyang1, D Okpako, E M Essien

  • 1Department of Pharmacology, College of Medicine, University of Ibadan, Nigeria.

African Journal of Medicine and Medical Sciences
|March 1, 1995
PubMed
Summary

Plasmodium berghei berghei infection in rats significantly reduces platelet survival and sialic acid levels. This finding may explain thrombocytopenia in malaria infections.

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Area of Science:

  • Parasitology
  • Hematology
  • Biochemistry

Background:

  • Thrombocytopenia is a common complication in malaria.
  • The underlying mechanisms of malaria-associated thrombocytopenia are not fully understood.

Purpose of the Study:

  • To investigate the impact of Plasmodium berghei berghei infection on platelet recovery, survival, and sialic acid content in Wistar rats.

Main Methods:

  • Wistar rats were infected with P. berghei berghei.
  • Platelet recovery and survival were assessed using 51Cr-labelled platelets.
  • Total platelet sialic acid was measured in infected and control rats.

Main Results:

  • Infected rats exhibited reduced platelet recovery and shortened platelet survival.

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  • Total platelet sialic acid content was significantly lower in infected rats.
  • The reduction in sialic acid correlated with parasitemia levels.

    • Conclusions:

    • Shortened platelet survival and reduced sialic acid content are causally linked in P. berghei infected rats.
    • These alterations may contribute to the thrombocytopenia observed in malaria.