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Accessory Glands of the Male Reproductive System01:16

Accessory Glands of the Male Reproductive System

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Related Experiment Video

Updated: Jul 24, 2026

Ultrasonographic Evaluation of Salivary Glands for Sjogren's Syndrome: Diagnostic and Monitoring Insights
07:25

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Primary Sjögren's syndrome in men

J M Anaya1, G T Liu, E D'Souza

  • 1Department of Medicine, University of Texas Health Science Center at San Antonio 78284-7874, USA.

Annals of the Rheumatic Diseases
|September 1, 1995
PubMed
Summary

Primary Sjögren

Area of Science:

  • Rheumatology
  • Immunology
  • Endocrinology

Background:

  • Primary Sjögren's syndrome (SS) is a chronic autoimmune disease primarily affecting exocrine glands.
  • While predominantly affecting women, SS can occur in men, presenting unique clinical considerations.

Purpose of the Study:

  • To delineate the clinical presentation of primary Sjögren's syndrome (SS) specifically in men.
  • To investigate the prevalence of extraglandular manifestations (EGM) and specific autoantibodies in male patients with primary SS.
  • To compare the clinical and serological profiles of primary SS in men versus women.

Main Methods:

  • A cross-sectional, comparative study involving adult men diagnosed with primary SS.
  • A control group of 26 age-matched adult women with primary SS was selected.

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Last Updated: Jul 24, 2026

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  • Patients were assessed based on European classification criteria for SS, comparing demographic, clinical, and laboratory findings.

    • Main Results:

    • Thirteen men with primary SS were identified, with a mean age of onset of 39 years.
    • Extraglandular manifestations (EGM) were present in 92% of men during the disease course, most commonly polyarthralgias and lymphopenia.
    • Serological markers including rheumatoid factor, antinuclear antibodies, anti-SS-A, and anti-SS-B were frequently detected, with no significant differences between sexes, though men showed a higher likelihood of EGM.

    Conclusions:

    • Primary Sjögren's syndrome in men is rare but shares clinical and serological similarities with female patients.
    • Extraglandular manifestations are common in men with primary SS.
    • The role of sex hormones in the pathogenesis and severity of primary SS warrants further investigation.