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Physiology and pathophysiology of complement: progress and trends

B P Morgan1

  • 1Department of Medical Biochemistry, University of Wales College of Medicine, Health Park, Cardiff.

Critical Reviews in Clinical Laboratory Sciences
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

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The complement system, a cascade of proteins, defends against bacteria and immune complexes. Research explores its role in diseases like neurological disorders and potential therapeutic applications.

Area of Science:

  • Immunology
  • Molecular Biology
  • Biochemistry

Background:

  • The complement system is a crucial part of innate immunity, involving over 20 plasma and membrane proteins.
  • It functions as a tightly regulated cascade to eliminate pathogens and clear immune complexes.
  • Deficiencies in the complement system lead to increased susceptibility to bacterial infections and immune complex diseases.

Purpose of the Study:

  • To review the fundamental mechanisms of complement activation and regulation.
  • To discuss the role of complement in various immunological and neurological diseases.
  • To highlight therapeutic strategies and novel physiological functions of the complement system.

Main Methods:

  • Review of existing literature on complement system mechanisms, activation, and biological roles.

Related Experiment Videos

  • Discussion of clinical research findings, including new assays for complement activation.
  • Summary of evidence regarding complement's involvement in disease and reproduction.

    • Main Results:

    • Complement activation involves a cascade of protein fragments with diverse functions.
    • Complement deficiencies are linked to specific diseases, particularly bacterial infections and immune complex disorders.
    • Emerging research implicates complement in neurological diseases and reproduction.

    Conclusions:

    • The complement system is vital for host defense and immune homeostasis.
    • Therapeutic inhibition of complement activation shows promise for treating complement-mediated diseases.
    • Further research is uncovering novel roles for complement in physiology and disease pathogenesis.