Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

T lymphocyte receptor deficiencies

D J Kappes1, B Alarcón, J R Regueiro

  • 1Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.

Current Opinion in Immunology
|August 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A window of opportunity for cooperativity in the T Cell Receptor.

Nature communications·2018
Same author

The 450 kDa TCR Complex has a Stoichiometry of alphabetagammaepsilondeltaepsilonzetazeta.

Scandinavian journal of immunology·2008
Same author

PCR-based procedures for detection and quantification of Staphylococcus aureus and their application in food.

Journal of applied microbiology·2006
Same author

[Results of infrainguinal revascularization in patients with end-stage renal disease].

Annales de chirurgie·2005
Same author

PCR detection of Listeria monocytogenes: a study of multiple factors affecting sensitivity.

Journal of applied microbiology·2003
Same author

Toward gene therapy for human CD3 deficiencies.

Human gene therapy·2003
Same journal

A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs.

Current opinion in immunology·2026
Same journal

Germinal center responses at barrier organ sites.

Current opinion in immunology·2026
Same journal

Ocular sarcoidosis: from clinical signs to targeted interventions.

Current opinion in immunology·2026
Same journal

On or within: spatial determinants of antigen handling in the nasal turbinates.

Current opinion in immunology·2026
Same journal

Decoding the complexity of intestinal immunity with spatial transcriptomics.

Current opinion in immunology·2026
Same journal

Reconsidering the immunological aspects of solid-phase assays for antiphospholipid antibodies detection.

Current opinion in immunology·2026
See all related articles

T-cell receptor (TCR) signaling relies on CD3 complex tails. CD3 deficiencies impact T-cell development and subsets, revealing unique and redundant roles of these critical molecules.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • T-cell receptor (TCR) signaling is crucial for adaptive immunity.
  • The CD3 complex, specifically its cytoplasmic tails, mediates TCR signal transduction.
  • Deficiencies in CD3 components disrupt T-cell development and function.

Purpose of the Study:

  • To investigate the functional consequences of CD3 component deficiencies.
  • To elucidate the distinct and overlapping roles of CD3 molecules in T-cell biology.
  • To gain insights from human patients and animal models with CD3 deficiencies.

Main Methods:

  • Analysis of human patients with CD3 deficiencies.
  • Studies utilizing animal models with genetic alterations in CD3 components.

Related Experiment Videos

  • Assessment of T-cell development and peripheral T-cell subset populations.

    • Main Results:

    • Expression deficiencies of different CD3 components result in significant and varied effects on T-cell development.
    • Selective deficits in peripheral T-cell subsets are observed in individuals with CD3 deficiencies.
    • Comparative studies highlight both redundant and unique functions of CD3 molecules.

    Conclusions:

    • CD3 components play essential, yet differentially regulated, roles in T-cell maturation and homeostasis.
    • Understanding CD3 deficiencies provides critical insights into TCR signaling pathways.
    • Targeted studies of CD3 deficiencies are key to deciphering T-cell subset regulation.