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Updated: Aug 11, 2026

One-channel Cell-attached Patch-clamp Recording
Published on: June 9, 2014
Chloride channels of intracellular organelles
1College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Abstract:
Chloride channels are present in a variety of intracellular organelles (Golgi, endosomes, endoplasmic reticulum, and sarcoplasmic reticulum) where they serve largely to shunt the membrane potential created by other ion-translocating processes. Electrophysiological studies have shown that the Cl- channels of the endoplasmic and sarcoplasmic reticula facilitate the efflux of Ca2+. In the Golgi and some endosomes, the open Cl- channels (probably the cystic fibrosis transmembrane conductance regulator) favor accumulation of H+.
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