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[Assessment for intelligence on patients with Pick's disease]

K Nagano¹, H Tanabe, H Kazui

¹Department of Neuropsychiatry, Osaka University Medical School, Suita, Japan.

No to Shinkei = Brain and Nerve

|November 1, 1995

Summary

Mini-Mental State (MMS) and Raven's Coloured Progressive Matrices (RCPM) tests show limited clinical utility in Pick's disease. Intelligence may be preserved in mild frontal cases but is obscured by "Denkfaulheit" in moderate/severe stages.

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Area of Science:

Neuropsychology
Neurology
Cognitive Science

Context:

Pick's disease, a form of frontotemporal dementia, presents diagnostic challenges.
The clinical utility of standard cognitive tests in Pick's disease remains under-evaluated.
Deterioration of intelligence in relation to dementia staging requires further investigation.

Purpose:

To evaluate the clinical usefulness of the Mini-Mental State (MMS) and Raven's Coloured Progressive Matrices (RCPM) in Pick's disease.
To determine if intelligence deteriorates with dementia staging in Pick's disease.
To investigate the impact of "Denkfaulheit" and "gogi" aphasia on cognitive test performance.

Summary:

Seventeen Pick's disease patients (7 frontal, 10 temporal atrophy) were assessed using MMS and RCPM, staged by the NM scale.
Frontal lobe atrophy cases showed "Denkfaulheit"; mild cases had preserved intelligence (normal RCPM), while moderate/severe cases were unassessable.
Temporal lobe atrophy cases exhibited "gogi" aphasia; severe cases also showed "Denkfaulheit".

Impact:

Findings suggest limited utility of MMS and RCPM in assessing intelligence in advanced Pick's disease, particularly with frontal lobe involvement.
The study highlights the confounding effects of specific cognitive deficits like "Denkfaulheit" and "gogi" aphasia.
This research informs the selection and interpretation of neuropsychological tests for patients with Pick's disease.