Hungarian population data for the STR systems TH01 and VWA

Area of Science:

• Forensic Genetics
• Population Genetics
• Human Genetics

Background:

• Short tandem repeat (STR) markers are crucial for human identification.
• Understanding population-specific allele frequencies is essential for forensic applications.

Purpose of the Study:

• To characterize the genetic variation of TH01 and VWA STR loci in a Hungarian Caucasian population.
• To provide population data for forensic and genetic studies.

Main Methods:

• Analysis of 244 unrelated Hungarian Caucasian individuals.
• High-resolution/non-denaturing horizontal polyacrylamide gel electrophoresis (PAGE).
• Genotyping for TH01 and VWA STR systems.

Main Results:

• Identified 7 alleles for TH01 and 8 alleles for VWA.
• Observed allele frequencies comparable to other European Caucasian populations.
• No mobility variations detected, except for VWA allele 14.
• Genotype distributions adhered to Hardy-Weinberg equilibrium.

Conclusions:

• The TH01 and VWA STR systems are polymorphic in the Hungarian Caucasian population.
• The observed allele frequencies support their utility in forensic casework within this population.
• Data contributes to the global STR database for population genetics and forensic science.