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Related Experiment Videos

Language comprehension in schizophrenia: trait or state indicator?

R Condray1, D P van Kammen, S R Steinhauer

  • 1Highland Drive VA Medical Center, University of Pittsburgh School of Medicine, PA 15206, USA.

Biological Psychiatry
|September 1, 1995
PubMed
Summary

Language comprehension in schizophrenia patients is consistently impaired, regardless of antipsychotic medication or placebo. This suggests comprehension deficits may be a stable trait in schizophrenia.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Linguistics

Background:

  • Language comprehension deficits are common in schizophrenia.
  • The impact of antipsychotic medication on these deficits requires further investigation.

Purpose of the Study:

  • To assess language comprehension in schizophrenic patients during haloperidol treatment and placebo.
  • To determine if comprehension is influenced by medication, positive or negative symptoms, or other patient characteristics.

Main Methods:

  • 15 male schizophrenic patients and 15 male controls were assessed.
  • Language comprehension was measured using the Luria-Nebraska Relational Concepts Factor Scale.
  • Patients were evaluated under haloperidol and placebo conditions.

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Main Results:

  • Schizophrenic patients showed significantly reduced language comprehension compared to controls.
  • No significant difference in comprehension was observed between haloperidol and placebo conditions.
  • Comprehension was not associated with positive symptoms, anxiety, depression, or monoamines.

Conclusions:

  • Language comprehension in schizophrenia appears independent of antipsychotic treatment and positive symptoms.
  • Comprehension deficits may represent a stable trait characteristic in schizophrenia.
  • Anhedonia-asociality was the only symptom associated with comprehension during haloperidol treatment.