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Control of drug-resistant tuberculosis
C S Lambregts-van Weezenbeek1, J Veen
1Royal Netherlands Tuberculosis Association, The Hague, The Netherlands.
Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
|October 1, 1995
Summary
Drug-resistant tuberculosis requires country-specific interventions due to varying causes. Evaluating the
Area of Science:
- Global Health
- Infectious Diseases
- Public Health Policy
Background:
- Drug-resistant tuberculosis (DR-TB) presents a significant global health challenge.
- The drivers of DR-TB and optimal intervention strategies can differ substantially between countries.
Purpose of the Study:
- To analyze the development and spread of drug-resistant tuberculosis.
- To discuss the roles of disease import and HIV in DR-TB.
- To propose a systematic approach for assessing DR-TB and define inadequate treatment.
Main Methods:
- Analysis of DR-TB development and spread.
- Discussion of disease import and HIV co-infection.
- Introduction of the 'treatment delivery process' (TDP) as a diagnostic tool.
- Quantitative and qualitative assessment of drug resistance.
Main Results:
- The causes of drug resistance necessitate tailored intervention strategies for each country.
- The 'treatment delivery process' (TDP) can be used to analyze the origins of acquired drug resistance.
- Intervention strategies should be informed by TDP evaluations.
Conclusions:
- Country-specific assessments are crucial for effective drug-resistant tuberculosis interventions.
- The 'treatment delivery process' (TDP) offers a framework for analyzing and addressing secondary drug resistance.
- Tailored strategies based on TDP evaluations are essential for combating global DR-TB.