[Trophoblastic interferons and embryonal immune tolerance]

J Martal1, M P De La Llosa-Hermier, N Chêne

  • 1INRA Unité d'Endocrinologie de l'Embryon, Jouyen-Josas.

Contraception, Fertilite, Sexualite (1992)
|September 1, 1995
PubMed

Current evidence support the hypothesis that trophoblast interferons play a key role in preventing maternal immunologal rejection of the embryonic semi-allograft. The information of this review is divided in two sections. In the first section we described molecular and biological characteristics of type I (alpha, beta, omega, tau and spl) and type II (gamma) interferons. In the second section we emphasize studies on immunoendocrine functions of IFN-tau (oTP-1 or trophoblastins) in the network of cytokines and hormonal environment at the uterine embryonic interface.

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