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[Lymphomatoid papulosis in a child]
C Léauté-Labrèze1, P Bioulac-Sage, G Belleannée
1Unité de dermatologie pédiatrique, hôpital Pellegrin-Enfants, Bordeaux, France.
Summary
Lymphomatoid papulosis (LyP) is rare in children, presenting benignly despite malignant-appearing histology. This case highlights a pediatric LyP diagnosis with a favorable outcome after surgical intervention.
Area of Science:
- Dermatology
- Pediatric Oncology
- Pathology
Background:
- Lymphomatoid papulosis (LyP) is an uncommon condition in children, characterized by a benign clinical course despite histological features suggestive of malignancy.
- The differential diagnosis of LyP can be challenging, particularly distinguishing it from CD30-positive lymphomas.
Observation:
- A 9-year-old boy presented with a 6-month history of nodular skin lesions on the scalp and penis, and a papule on the trunk.
- Scalp nodules were surgically excised to prevent necrosis and ulceration.
- Biopsies revealed a mixed cellular infiltrate with atypical large cells, a minority expressing the CD30 antigen. TCR gamma chain gene rearrangement was oligoclonal.
Findings:
- The patient's physical examination, bone marrow aspirate, and CT scans were normal, ruling out systemic involvement.
- Three years post-surgery, no new lesions have appeared, indicating a positive prognosis in this pediatric case.
- The findings underscore the importance of thorough evaluation and follow-up in pediatric LyP.
Implications:
- This case emphasizes the diagnostic difficulty and prognostic uncertainty of LyP, especially in differentiating it from non-Hodgkin's lymphoma.
- It highlights the potential for a favorable outcome in pediatric LyP with appropriate management.
- Further research is needed to better understand the long-term behavior and optimal treatment strategies for LyP in children.