Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prolonged muscular flaccidity after stroke. Morphological and functional brain alterations

P Pantano1, R Formisano, M Ricci

  • 1Department of Neurological Sciences, University of Rome La Sapienza, Italy.

Brain : a Journal of Neurology
|October 1, 1995
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Resting state functional thalamic connectivity abnormalities in patients with post-stroke sleep apnoea: a pilot case-control study.

European review for medical and pharmacological sciences·2017
Same author

White matter changes and ventricular enlargement on magnetic resonance imaging: Comparison between normal elderly subjects and patients with cerebrovascular disorders.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2015
Same author

Differential Influence of Carotid Stenosis and White Matter Disease on Motor and Cognitive Activation.

Current Alzheimer research·2015
Same author

Enlarging brain xanthomas in a patient with cerebrotendinous xanthomatosis.

Journal of inherited metabolic disease·2015
Same author

Correlates of leukoaraiosis and ventricular enlargement on magnetic resonance imaging: a study in normal elderly and cerebrovascular patients.

European journal of neurology·2013
Same author

Predictors and timing of recanalization in intracranial carotid artery and siphon dissection: an ultrasound follow-up study.

Cerebrovascular diseases (Basel, Switzerland)·2013

Prolonged muscular flaccidity after ischemic stroke, unlike spasticity, is linked to lentiform nucleus damage. Reduced blood flow in key motor control areas, including the thalamus and cerebellum, also contributes to flaccidity.

Area of Science:

  • Neuroscience
  • Neurology
  • Radiology

Background:

  • Ischemic stroke can lead to motor deficits, typically muscular spasticity, but sometimes prolonged muscular flaccidity, hindering recovery.
  • The underlying causes for these divergent functional outcomes post-stroke remain poorly understood.

Purpose of the Study:

  • To investigate the neuroanatomical and perfusion correlates of prolonged muscular flaccidity versus muscular spasticity following ischemic stroke.
  • To identify specific brain regions and their functional roles in determining post-stroke motor recovery patterns.

Main Methods:

  • Correlative analysis of neuroimaging (CT/MRI, 99mTc HM-PAO SPECT) with clinical findings in 42 post-stroke patients.
  • Patients categorized into prolonged muscular flaccidity or muscular spasticity hemiparesis cohorts.

Related Experiment Videos

  • Assessment of lesion volume, structural involvement (especially lentiform nucleus), and relative regional cerebral blood flow (rCBF).

    • Main Results:

    • Mean lesion volume was similar between flaccidity and spasticity groups, despite greater motor deficit in the flaccidity cohort.
    • Significantly higher prevalence of lentiform nucleus involvement in the prolonged muscular flaccidity group.
    • Lower relative perfusion observed in the lentiform nucleus, thalamus, and contralateral cerebellar hemisphere in flaccidity patients compared to spasticity patients.
    • Subgroup analysis revealed reduced ipsilateral frontal association area perfusion in cases with only subcortical lesions.

    Conclusions:

    • Primary structural damage to the lentiform nucleus appears critical for the persistence of flaccidity after ischemic stroke.
    • Altered cerebral blood flow in structurally intact regions, particularly within subcortical-cortical motor loops (basal ganglia and cerebellum pathways), significantly contributes to prolonged flaccidity.
    • Both structural integrity and functional perfusion of motor control circuits are crucial for determining post-stroke motor outcomes.