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Resection of brain metastases from sarcoma
1Neurosurgery Service, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Annals of Surgical Oncology
|September 1, 1995
Summary
Surgical excision is recommended for brain metastases from sarcoma when feasible, as these are rare and often refractory to other treatments. Long-term survival is possible for some patients, even with lung metastasis.
Area of Science:
- Oncology
- Neurosurgery
- Sarcoma Research
Background:
- Brain metastases from sarcoma are infrequent, with limited data on treatment outcomes.
- Sarcoma brain metastases typically occur with or after lung metastases.
Purpose of the Study:
- To evaluate the treatment and outcomes of surgically managed brain metastases from sarcoma.
- To identify prognostic factors for survival in patients with sarcoma brain metastases.
Main Methods:
- Retrospective review of 25 patients with sarcoma brain metastases treated surgically over 20 years.
- Analysis of patient demographics, metastasis location, presence of lung metastases, and survival data.
Main Results:
- The median age at diagnosis of brain metastasis was 25 years.
- 19 patients had lung metastases, often synchronous with brain lesions.
- Median survival from craniotomy was 7 months, with 40% 1-year survival and 16% 2-year survival.
Conclusions:
- Surgical excision is indicated for brain metastases from sarcoma when feasible due to refractoriness to other treatments.
- Long-term survival can be achieved in select patients.
- Sarcoma brain metastases are uncommon and usually associated with pulmonary disease.