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Exocrine pancreatic function in diabetes mellitus

G Gröger1, P Layer

  • 1Department of Medicine, University of Essen, Germany.

European Journal of Gastroenterology & Hepatology
|August 1, 1995
PubMed
Summary

In insulin-dependent diabetes mellitus, exocrine pancreas function and morphology are altered, but nutrient digestion is likely unaffected. The exact cause, whether related to beta-cell dysfunction or common immunology, requires further investigation.

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Area of Science:

  • Endocrinology
  • Gastroenterology
  • Immunology

Background:

  • The exocrine pancreas and pancreatic islet system exhibit complex interrelations.
  • Alterations in exocrine pancreatic function and morphology are observed in insulin-dependent diabetes mellitus (IDDM).
  • The precise mechanisms underlying these changes in humans remain unclear.

Purpose of the Study:

  • To investigate the functional and morphological changes in the exocrine pancreas in IDDM.
  • To determine if these exocrine changes are a consequence of disturbed islet (beta-cell) function or a shared immunological pathogenesis.

Main Methods:

  • The abstract does not specify the methods used.
  • Further research is needed to elucidate the mechanisms.

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Main Results:

  • Reduced pancreatic secretion in IDDM is unlikely to impair intraluminal nutrient digestion.
  • Exocrine pancreatic function and morphology appear altered in IDDM patients.

Conclusions:

  • The relationship between exocrine pancreatic changes and islet (beta-cell) dysfunction in IDDM requires further clarification.
  • A common immunological basis for both exocrine and endocrine pancreatic alterations in IDDM is a possibility that warrants further study.