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Helicobacter pylori and acute bleeding peptic ulcer
A E Henriksson1, A C Edman, M Held
1Department of Surgery, Sundsvall County Hospital, Sweden.
European Journal of Gastroenterology & Hepatology
|August 1, 1995
Summary
Helicobacter pylori (H. pylori) infection is a significant cause of acute bleeding peptic ulcers. High prevalence rates were found in patients with gastric and duodenal ulcers, confirming its etiological role.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Clinical Medicine
Background:
- Helicobacter pylori (H. pylori) is a known factor in chronic peptic ulcer disease.
- The role of H. pylori in acute bleeding peptic ulcers requires further investigation.
Purpose of the Study:
- To determine the frequency of H. pylori infection in patients presenting with acute bleeding peptic ulcers.
- To assess the etiological significance of H. pylori in this patient group.
Main Methods:
- A prospective study was conducted involving seventy consecutive patients with acute bleeding peptic ulcers.
- H. pylori infection was diagnosed using two serological tests (latex immunoassay and ELISA) on admission and at follow-up.
- Endoscopy was used for diagnosis verification and healing assessment; patient history and NSAID use were recorded.
Main Results:
- The enzyme-linked immunosorbent assay (ELISA) detected H. pylori antibodies in 81% of gastric ulcer patients and 85% of duodenal ulcer patients.
- A commercial latex immunoassay showed lower prevalence rates (53% for gastric, 62% for duodenal ulcers).
- High sensitivity and specificity ELISA results strongly correlate H. pylori with acute bleeding ulcers.
Conclusions:
- H. pylori infection plays a substantial etiological role in the development of acute bleeding peptic ulcers.
- The findings underscore the importance of H. pylori testing in managing patients with acute bleeding peptic ulcers.