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Related Experiment Videos

Autologous peripheral stem-cell transplantation

H Handelsman1

  • 1U.S. Department of Health and Human Services Public Health Service Agency for Health Care Policy and Research Rockville, MD, USA.

Health Technology Assessment
|August 1, 1995
PubMed
Summary
This summary is machine-generated.

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Autologous peripheral stem-cell transplantation (APSCT) effectively supports cancer patients after high-dose chemotherapy. Peripheral stem cells (PSC) provide satisfactory hematopoietic reconstitution (HR), comparable to autologous bone marrow transplantation (ABMT).

Area of Science:

  • Hematology
  • Oncology
  • Transplantation Medicine

Background:

  • Autologous peripheral stem-cell transplantation (APSCT) is crucial for cancer patients undergoing high-dose chemotherapy (HDCT).
  • HDCT can cause prolonged or irreversible myelosuppression, necessitating hematopoietic reconstitution (HR).
  • APSCT involves harvesting, cryopreserving, and reinfusing a patient's own progenitor cells for HR.

Purpose of the Study:

  • To assess the safety, efficacy, and cost-effectiveness of using peripheral stem cells (PSC) for HR in APSCT.
  • To review patient selection criteria and indications for APSCT.
  • To compare APSCT with autologous bone marrow transplantation (ABMT).

Main Methods:

  • Review of available information from study panels, research centers, institutions, and government agencies.

Related Experiment Videos

  • Discussion of randomized clinical trials and their limitations.
  • Comparison of HR rates and patient outcomes between APSCT and ABMT.

    • Main Results:

    • Peripheral stem cells (PSC) can provide satisfactory hematopoietic reconstitution (HR).
    • The rate of HR using PSC is comparable to that of autologous bone marrow transplantation (ABMT).
    • Current techniques for CD34+ cell separation in APSCT reduce tumor cell infusion compared to unseparated PSC.

    Conclusions:

    • Existing evidence supports the use of PSC for satisfactory HR in APSCT.
    • The clinical significance of HR via PSC is secondary to the antitumor benefits of HDCT.
    • APSCT using PSC is a viable option for supporting cancer patients post-HDCT.