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Published on: September 17, 2021
Cocaine-associated chest pain: one-year follow-up
J E Hollander1, R S Hoffman, P Gennis
1Department of Emergency Medicine, University Hospital, State University of New York, Stony Brook 11794-7400, USA.
Insights
Patients with chest pain from cocaine use have a low one-year risk of death or heart attack (myocardial infarction, MI). Continued cocaine use is common and linked to recurrent chest pain, underscoring the need for cessation interventions.
Area of Science:
- Cardiology
- Emergency Medicine
- Toxicology
Background:
- Cocaine use is a significant cause of chest pain presentations to emergency departments.
- The long-term cardiac outcomes for patients experiencing cocaine-associated chest pain are not well-established.
Purpose of the Study:
- To assess one-year mortality and myocardial infarction (MI) rates after hospital discharge or ED release in patients with cocaine-associated chest pain.
Main Methods:
- A prospective, observational study followed 203 patients presenting with cocaine-associated chest pain.
- Patients were monitored for one year to determine survival and nonfatal MI incidence.
Main Results:
- One-year actuarial survival was 98%, with no deaths attributed to MI.
- Nonfatal myocardial infarction (MI) occurred in only 1% of patients.
- Sixty percent of patients continued cocaine use, associated with recurrent chest pain; no MI or death occurred in those who ceased use.
Conclusions:
- Patients with cocaine-associated chest pain have a low subsequent risk of MI and death if MI is ruled out and pain is not recurrent.
- Urgent cardiac evaluations may not be necessary for all patients in this cohort.
- Emphasis on cocaine cessation is crucial for intervention strategies.
Objective:
To determine the one-year mortality and incidence of myocardial infarction (MI) post-hospital discharge or ED release for patients with cocaine-associated chest pain.
Methods:
A prospective, observational study of an inception cohort of consecutive patients who presented to one of four municipal hospital EDs with cocaine-associated chest pain. Patients were followed for one year from the end of the enrollment period. Main outcome parameters were the one-year actuarial survival and the frequency of nonfatal MI.
Results:
Mortality data were available for all 203 patients at a mean of 408 days. Additional clinical information was available for 185 patients (91%). There were six deaths (one-year actuarial survival 98%; 95% CI, 95-100%); none from MI. Nonfatal MI occurred in two patients (1%; 95% CI, 0-2%). Continued cocaine use was common (60%; 95% CI, 52-68%) and was associated with recurrent chest pain (75% vs 31%, p < 0.0001). No MI or death was reported for patients who claimed to have ceased cocaine use.
Conclusions:
Patients who presented with cocaine-associated chest pain commonly continued to use cocaine after discharge. Urgent evaluation of coronary anatomy or cardiac stress tests may not be necessary for patients for whom MI is ruled out and who do not have recurrent potentially ischemic pain. The subsequent risk for MI and death in this group appears to be low. Intervention strategies should emphasize cessation of cocaine use.
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