Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ordering clone libraries in computational biology

M Dyer1, A Frieze, S Suen

  • 1School of Computer Studies, University of Leeds, UK.

Journal of Computational Biology : a Journal of Computational Molecular Cell Biology
|January 1, 1995
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Challenges and opportunities of predicting overall survival benefit from improvements to recurrence-free survival in stage II/III melanoma: a correlation meta-analysis.

Immuno-oncology technology·2025
Same author

SF-CORNER (splenic flexure colorectal cancer): an international survey of operative approaches and outcomes for cancers of the splenic flexure.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2024
Same author

Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia.

Leukemia·2016
Same author

Cost-Effectiveness Analysis of Testing for Brca Mutations in Women Diagnosed with Ovarian Cancer and their Female First-Degree Relatives: A Uk Health Service Perspective.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research·2016
Same author

Outcome of high-risk pregnancies in a community health centre.

Canadian family physician Medecin de famille canadien·2011
Same author

Cost analysis of an integrated care model in the management of acute exacerbations of chronic obstructive pulmonary disease.

Chronic respiratory disease·2009
Same journal

GMSA: A Graph Matching and Point Cloud Registration-Based Method for Spatial Transcriptomics Data Alignment.

Journal of computational biology : a journal of computational molecular cell biology·2026
Same journal

Investigations on Multiple Protein Scaffold Filling.

Journal of computational biology : a journal of computational molecular cell biology·2026
Same journal

Cell Type Prediction for Single-Cell RNA Sequencing Utilizing Unsupervised Domain Adaptation and Semi-Supervised Learning.

Journal of computational biology : a journal of computational molecular cell biology·2026
Same journal

PPIGAN: Prediction of Protein-Protein Interactions Using Generative Adversarial Networks.

Journal of computational biology : a journal of computational molecular cell biology·2026
Same journal

Deep Structure-Enhanced Cell Clustering Model for Single-Cell RNA Sequencing Data.

Journal of computational biology : a journal of computational molecular cell biology·2026
Same journal

Asymmetric Drug-Drug Interaction Prediction Based on Generative Adversarial Networks and Knowledge Graph.

Journal of computational biology : a journal of computational molecular cell biology·2026
See all related articles

This study addresses DNA physical mapping using a probabilistic model. It determines the minimum probes needed for high-probability DNA clone library ordering and tiling, providing precise characterizations.

Area of Science:

  • Genomics
  • Computational Biology
  • Bioinformatics

Background:

  • Probabilistic models are crucial for DNA physical mapping.
  • Previous work by Lander & Waterman and Alizadeh et al. established foundational models.
  • Understanding probe requirements is key for efficient DNA mapping.

Purpose of the Study:

  • To precisely answer Alizadeh et al.'s question on minimum probes for DNA clone library ordering.
  • To investigate the minimum probes needed for constructing a DNA library tiling.
  • To provide a precise characterization of these probe numbers.

Main Methods:

  • Utilized a probabilistic model for DNA physical mapping.
  • Analyzed probe requirements within the established Lander-Waterman and Alizadeh et al. frameworks.

Related Experiment Videos

  • Applied mathematical and statistical analysis to determine probe number thresholds.

    • Main Results:

    • Determined the minimum number of probes for high-probability reconstruction of DNA clone library order.
    • Characterized the minimum probes required for creating a library tiling.
    • Provided precise quantitative insights into probe efficiency.

    Conclusions:

    • The study offers precise answers regarding probe efficiency in DNA mapping.
    • Findings contribute to optimizing experimental design in genomics and bioinformatics.
    • The characterizations advance the understanding of DNA physical mapping methodologies.