The development of laboratory tests for cancer in Japan with special reference to carcinoembryonic proteins

The present paper describes the present status of clinical tests for cancer in Japan. Since no cancer-specific substance has been found so far the clinical tests for cancer at present are always quantitative but not qualitative. Among these substances, alpha-fetoprotein is one of the most specific substances for cancer and its test is essential for diagnosis of hepatoma beins used worldwide. AFP is a specific product of liver cancer cells. The measurement of carcinoembryonic antigen in patient blood is a hopeful method for cancer diagnosis. This substance is not specifically produced by cancer cells, but the phenomenon of appearance in bloodstream appears to be cancer-specific. This may reflect the invasion of blood vessels in tissues such as colorectum, lung, etc., by infiltration of cancer cell. This is the reason for the appearance of CEA in a wide variety of cancers. There are many other clinical tests at present but these are only secondary aids for the diagnosis of cancer. This is the reason why the description concentrates mostly on AFP and CEA. The companies manufacturing the kits for these tests in Japan are also listed in this paper.