A late increase in free radical activity post myocardial infarction
A B Bridges1, G P McNeill, T H Pringle
1University Department of Medicine, Ninewells Hospital and Medical School, Dundee, Scotland, U.K.
European Heart Journal
|July 1, 1995
Summary
Free radical activity, indicated by increased malondialdehyde and decreased plasma thiols, is elevated seven days after myocardial infarction (MI). This enhanced free radical activity may reflect the body
Area of Science:
- Biochemistry
- Cardiology
- Pathophysiology
Background:
- Free radicals (FR) are implicated in reperfusion injury following myocardial infarction (MI).
- FR scavengers may benefit acute MI patients treated with thrombolysis.
- Previous studies focused on immediate post-reperfusion FR activity.
Purpose of the Study:
- Investigate FR activity in acute MI patients over a longer time span (admission, day 7, day 21).
- Assess indirect markers of FR activity: malondialdehyde (MDA) and plasma thiols (PSH).
Main Methods:
- Blood samples collected from 22 acute MI patients on admission, day 7, and day 21.
- Measured levels of MDA (FR product) and PSH (FR scavenger).
Main Results:
- Significant increase in MDA levels on day 7 post-MI (P=0.0001).
- Significant decrease in PSH levels on day 7 post-MI (P=0.04).
- No significant changes in MDA or PSH levels between admission and day 21.
Conclusions:
- Enhanced free radical activity is present later post-MI than previously recognized.
- Late rise in FR activity may be linked to white blood cell removal of necrotic myocardium.
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