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Related Experiment Videos

Autoimmune phenomena in psoriasis

S Jabłońska, M Jarzabek-Chorzelska, E Maciejowska

    Archivum Immunologiae Et Therapiae Experimentalis
    |January 1, 1978
    PubMed
    Summary
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    Stratum corneum (SC) antibodies are found in all human sera and bind to psoriatic lesions. These antibodies activate complement, suggesting their role in the development of psoriasis.

    Area of Science:

    • Immunology
    • Dermatology
    • Autoimmunity

    Background:

    • Stratum corneum (SC) antibodies are detected in human sera.
    • These antibodies may play a role in autoimmune skin conditions.

    Purpose of the Study:

    • To investigate the presence and function of SC antibodies in psoriasis.
    • To determine if SC antibodies bind to psoriatic lesions and activate complement.

    Main Methods:

    • Indirect immunofluorescence (IF) staining of human sera and psoriatic lesions.
    • Complement fixation tests using anti-C4 and anti-C3 conjugates.

    Main Results:

    • SC antibodies were present in all tested human sera.
    • Antibodies were observed to bind in vivo to the stratum corneum of psoriatic lesions.

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  • Psoriatic scales showed coating with IgG and, in most cases, complement.

    • Conclusions:

    • SC antibodies and complement fixation are indirectly evidenced to participate in psoriasis development.
    • These findings suggest a potential autoimmune mechanism in psoriasis involving SC antibodies.