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Related Experiment Videos

The pentadecapeptide [Ser1]histogranin impairs passive avoidance learning in mice

T Maurice1, A Privat, S Lemaire

  • 1I.N.S.E.R.M. U. 336, Ecole Nationale Supérieure de Chimie, Montpellier, France.

European Journal of Pharmacology
|September 5, 1995
PubMed
Summary

[Ser1]histogranin impairs passive avoidance learning in mice, similar to NMDA receptor antagonists. A specific antagonist, histogranin-(1-10), prevented this impairment, suggesting targeted histogranin sites are involved.

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Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Histogranin and [Ser1]histogranin modulate NMDA receptor function.
  • Understanding their role in learning and memory is crucial.

Purpose of the Study:

  • To investigate the effects of [Ser1]histogranin and its antagonist on passive avoidance learning in mice.
  • To elucidate the mechanism of [Ser1]histogranin's action on learning.

Main Methods:

  • Intracerebroventricular administration of [Ser1]histogranin and histogranin-(1-10) in mice.
  • Assessment of learning and memory using a step-down passive avoidance task.
  • Evaluation of drug effects on training, retention, and co-administration effects.

Main Results:

  • Post-training [Ser1]histogranin administration (30-60 nmol) impaired learning retention.

Related Experiment Videos

  • [Ser1]histogranin did not affect retention when given before the retention test.
  • Histogranin-(1-10) (60 nmol) facilitated learning during training but did not affect retention.
  • Co-administration of histogranin-(1-10) prevented [Ser1]histogranin-induced learning impairment.

    • Conclusions:

    • [Ser1]histogranin impairs passive avoidance learning in a manner consistent with NMDA receptor antagonists.
    • Specific histogranin receptor sites are involved in mediating these learning effects.
    • Histogranin-(1-10) acts as a functional antagonist, blocking the detrimental effects of [Ser1]histogranin on learning.