Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Studies on the Koebner phenomenon

S Jabłońska, M Jarzabek-Chorzelska, E Maciejowska

    Archivum Immunologiae Et Therapiae Experimentalis
    |January 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Streptomycin-oxytetracycline combined therapy; correlation between in vivo and in vitro trials.

    Antibiotics & chemotherapy (Northfield, Ill.)·2014
    Same author

    Further studies on retional in vitro bacterial sensitivity testing to nitrofurantoin.

    Antibiotics & chemotherapy (Northfield, Ill.)·2014
    Same author

    IgG4 as the predominant IgG subclass in pemphigoides gestationis.

    Journal of cutaneous pathology·2006
    Same author

    Complement-fixing properties of antinuclear antibodies distinguish drug-induced lupus from systemic lupus erythematosus.

    Lupus·2004
    Same author

    Pemphigus herpetiformis with IgA and IgG antibodies to desmoglein 1 and IgG antibodies to desmocollin 3.

    Journal of the American Academy of Dermatology·2003
    Same author

    Immunopathological diagnosis of pemphigus foliaceus.

    Dermatology (Basel, Switzerland)·2002

    Koebner reactions in psoriasis patients show stratum corneum (SC) antibodies near lesions. Widespread SC antibody deposits may signal impending psoriasis, while localized deposits might resolve without disease development.

    Area of Science:

    • Immunodermatology
    • Histopathology
    • Psoriasis Pathogenesis

    Background:

    • The Koebner phenomenon describes skin lesion development at sites of injury in patients with psoriasis.
    • Understanding the immunological basis of induced psoriasis lesions is crucial for early diagnosis and intervention.

    Purpose of the Study:

    • To investigate the role of stratum corneum (SC) antibodies in induced Koebner reactions in psoriasis patients.
    • To determine if the presence and extent of SC antibody deposits correlate with the development of clinical psoriasis.

    Main Methods:

    • Immunofluorescence (IF) and histological examination of skin biopsies from 71 patients with induced Koebner reactions.
    • Assessment of SC antibody binding at selected time points after experimental scratching.

    Related Experiment Videos

    Main Results:

    • Immunologically specific SC antibody reactions were observed adjacent to crusts in both controls and psoriasis patients.
    • Psoriasis patients showed progressive development of additional foci of in vivo SC antibody binding in scratched lesions.
    • IF deposits of SC antibodies could precede histological or clinical changes of psoriasis.

    Conclusions:

    • Widespread immune deposits in the stratum corneum, coupled with typical histological changes, may indicate impending clinical psoriasis.
    • Single foci of in vivo bound SC antibodies can be cleared by the body, potentially without the development of psoriasis.