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[Morphological study on the gastric mucosa in diabetes mellitus rats induced by streptozotocin]
T Watanabe1, A Asanuma, M Tanaka
1Fuji Research Laboratories, Kowa Co., Ltd., Shizuoka, Japan.
Abstract:
To clarify the pathogenesis of vulnerability to acute gastric mucosal lesion (AGML) in diabetes mellitus (DM), we investigated histopathologically the gastric mucosa of the fundic gland in streptozotocin-induced DM rats. The length of the mucosa and the thickness of the surface epithelial cell (SEC) layer were measured, and the number of proliferating cell nuclear antigen (PCNA) positive cells was counted. As results, compared with control rats, the ratio of the length of SEC layer to that of mucosa, and the number of PCNA positive cells were significantly decreased in DM rats, whereas the length of the mucosa tended to extend in DM rats. Consequently, it is considered that attenuation of mucosal barrier in the SEC layer can be closely associated with susceptibility to occurrence of AGML in DM.
Insights
Diabetes mellitus (DM) increases susceptibility to acute gastric mucosal lesions (AGML). In DM rats, a thinner surface epithelial cell (SEC) layer and reduced cell proliferation impair the gastric mucosal barrier, contributing to AGML.
Area of Science:
- Gastroenterology
- Endocrinology
- Pathology
Context:
- Diabetes mellitus (DM) is associated with an increased risk of gastrointestinal complications.
- Acute gastric mucosal lesions (AGML) are a potential complication in diabetic patients.
- The specific mechanisms underlying this vulnerability remain incompletely understood.
Purpose:
- To elucidate the histopathological basis of increased susceptibility to acute gastric mucosal lesions (AGML) in the context of diabetes mellitus (DM).
- To investigate alterations in the gastric mucosa of the fundic gland in streptozotocin-induced diabetic rats.
Summary:
- Histopathological analysis of gastric mucosa in diabetic rats revealed a decreased ratio of the surface epithelial cell (SEC) layer length to the overall mucosal length.
- A significant reduction in the number of proliferating cell nuclear antigen (PCNA)-positive cells was observed in diabetic rats compared to controls.
- These findings suggest that impaired SEC layer integrity and reduced cell proliferation contribute to a weakened gastric mucosal barrier in DM.
Impact:
- This study highlights the compromised gastric mucosal barrier in diabetes as a key factor in AGML pathogenesis.
- Understanding these mechanisms can inform the development of targeted therapeutic strategies for preventing gastric lesions in diabetic individuals.
- The research provides a histopathological basis for the gastrointestinal manifestations observed in diabetes mellitus.
